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KMID : 1130620120080040305
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Journal of Clinical Neurology
2012 Volume.8 No. 4 p.305 ~ p.307
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A Case of Lambert-Eaton Myasthenic Syndrome with Small-Cell Lung Cancer and Transient Increase in Anti-Acetylcholine-Receptor-Binding Antibody Titer
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Lee Jung-Hwan
Shin Ha-Young
Kim Seung-Min
Sunwoo Il-Nam
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Abstract
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Background: Lambert-Eaton myasthenic syndrome (LEMS) is a presynaptic neuromuscular junction disorder that is most frequently associated with small-cell lung cancer (SCLC). The titers of antibodies against voltage-gated calcium channels are frequently increased in LEMS, but only rarely is titer of anti-acetylcholine-receptor-binding antibodies (AChR-abs) increased.
Case Report: A 57-year-old male was admitted to our hospital due to dry mouth and eyes and progressive proximal limb weakness of 2 months duration. The results of a repetitive nerve stimulation test disclosed all criteria for the electrophysiological LEMS pattern, and the patient’s AChRabs titer was 0.587 nmol/L. At a follow-up performed 5 years after successful treatment of SCLC and LEMS, his AChR-abs titer had decreased to 0.001 nmol/L.
Conclusions: We suggest that this was a case of transient pseudopositivity of AChR-abs in SCLC with LEMS.
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KEYWORD
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Lambert-Eaton myasthenic syndrome, small-cell lung carcinoma, myasthenia gravis
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